Sharks prop Toby Rudolf suffered an MCL injury in the second half of Saturday's victory over the Wests Tigers and will be sent for scans to determine the severity of the injury.
Cronulla coach Craig Fitzgibbon confirmed the injury post-match, which Rudolf suffered away from contact.
It came after the Sharks lost centre Siosifa Talakai to a shoulder injury in the lead up to the match in Tamworth.
Later on Saturday night, Brisbane forward Kobe Hetherington failed an HIA following a head clash with Sauaso Sue in the second half of his side's victory over the Knights. The Broncos left centre Brenko Lee out of the squad after he suffered hamstring tightness during the week at training.
Newcastle coach Adam O'Brien said following the match that he was hopeful David Klemmer would be available in round 23 after the prop missed the trip to Brisbane with a knee issue.
Rabbitohs halfback Lachlan Ilias was a late withdrawal from Friday's clash against Parramatta after picking up a hamstring injury during the week.
Panthers forward Liam Martin left the field in the 49th minute of Thursday night's clash against the Storm after rolling his ankle and will be sent for scans to ascertain the seriousness of the injury.
The premiers had already lost winger Taylan May to a shoulder injury earlier in the week and fullback Dylan Edwards on game day with a sternum injury.
Meanwhile, the Raiders will be without inspirational prop Joseph Tapine for their crucial clash with the Dragons due to the rib injury.
Casualty Ward By Club
The Sea Eagles are down a key forward with Taniela Paseka sidelined by a knee injury. Sean Keppie is also still troubled by a shoulder injury and will miss another week.
Titans hooker Aaron Booth suffered a multi-ligament knee injury 14 minutes into last week's clash against the Storm, with the club confirming that Booth would require a full reconstruction as well as an extensive rehabilitation.
Storm halfback Jahrome Hughes missed the side's win over Penrith after injuring his shoulder in Round 21.
Cronulla five-eighth Matt Moylan missed last week's local derby with a quad injury and has not been named to face the Tigers this week. The Sharks are also without fullback Will Kennedy, who will be out of action until the finals after undergoing ankle surgery.
Warriors forward Jazz Tevaga will undergo shoulder surgery and miss the remainder of the season.
Parramatta halfback Mitchell Moses is hoping to be back in Round 24 after having surgery on a broken finger suffered against Penrith in Round 20.
To view the complete NRL Casualty Ward, please visit the hub page.
Chemist Warehouse Casualty Ward
- Kobe Hetherington (head knock, TBC)
- Brenko Lee (hamstring, TBC)
- Albert Kelly (foot, round 23)
- TC Robati (arm, round 23)
- Patrick Carrigan (suspension, round 25)
- Herbie Farnworth (biceps, indefinite)
- Ryan Sutton (head knock, round 22)
- Xavier Savage (ankle, round 22)
- Joseph Tapine (ribs, round 23)
- Nick Cotric (suspended, round 23)
- Jarrod Croker (shoulder, season)
- Josh Hodgson (knee, season)
- Harley Smith-Shields (knee, season)
- Tevita Pangai jnr (personal reasons, round 23)
- Corey Waddell (suspended, round 25)
- Corey Allan (groin, round 25)
- Reece Hoffman (hand, round 25)
- Luke Thompson (concussion, indefinite)
- Jack Hetherington (shoulder, season)
- Billy Tsikrikas (knee, season)
- Toby Rudolf (knee, TBC)
- Siosifa Talakai (shoulder, round 23)
- Connor Tracey (head knock, round 23)
- Matt Moylan (quad, round 23)
- Sione Katoa (shoulder, season)
- Jack Williams (shoulder, season)
Gold Coast Titans
- Joe Vuna (knee, indefinite)
- Shallin Fuller (leg, season)
- Aaron Booth (knee, season)
NRL Unpacked: New ball-tracking technology
Manly-Warringah Sea Eagles
- Josh Aloiai (knee, round 22)
- Kieran Foran (hamstring, round 22)
- Taniela Paseka (knee, round 23)
- Sean Keppie (shoulder, indefinite)
- Tom Trbojevic (shoulder, season)
- Karl Lawton (knee, season)
- Jahrome Hughes (shoulder, round 23-24)
- Felise Kaufusi (personal reasons, indefinite)
- Tepai Moeroa (shoulder, round 23)
- Trent Loiero (back, indefinite)
- Ryan Papenhuyzen (knee, season)
- Reimis Smith (pectoral, season)
- Christian Welch (achilles, season)
- George Jennings (knee, season)
- David Klemmer (knee, round 23)
- Mitch Barnett (thumb, round 25)
- Kurt Mann (quad, round 25)
- Chris Vea'ila (leg, indefinite)
- Kalyn Ponga (concussion, indefinite)
- Jake Clifford (arm, season)
- Leo Thompson (hamstring, season)
- Lachlan Fitzgibbon (shoulder, season)
- Bailey Hodgson (elbow, season)
- Dylan Lucas (pectoral, season)
Injury spotters and independent doctors
North Queensland Cowboys
- Kyle Feldt (hamstring, round 23)
- Mitch Dunn (knee, season)
- Heilum Luki (knee, season)
- Bailey Simonsson (hamstring, round 23)
- Mitchell Moses (finger, round 24-25)
- Nathan Brown (finger, TBC)
- Haze Dunster (knee, season)
- Ray Stone (knee, season)
- Liam Martin (ankle, TBC)
- Dylan Edwards (sternum, TBC)
- Taylan May (shoulder, round 23-24)
- James Fisher-Harris (suspended, round 24)
- Nathan Cleary (suspension, finals)
- Jarome Luai (knee, finals)
South Sydney Rabbitohs
- Lachlan Ilias (hamstring, TBC)
- Peter Mamouzelos (wrist, round 23)
- Thomas Burgess (groin, round 23)
- Campbell Graham (cheekbone, round 23)
- Jed Cartwright (hamstring, round 23)
- Kodi Nikorima (hamstring, round 24)
- Michael Chee Kam (thumb, round 25)
- Liam Knight (knee, season)
- Jacob Host (shoulder, season)
St George Illawarra Dragons
- Cody Ramsey (knee, round 22-23)
- Jayden Sullivan (shoulder, round 23)
- Mikaele Ravalawa (hamstring, finals)
- Moses Suli (ankle, finals)
- Tariq Sims (suspended, finals)
The VB Hard Earned Index explained
- Lindsay Collins (concussion, round 23)
- Siosiua Taukeiaho (cheekbone, round 23)
- Billy Smith (knee, season)
- Sitili Tupouniua (knee, season)
- Aaron Pene (leg, round 23)
- Jesse Arthars (quad, round 23)
- Chanel Harris-Tavita (knee, round 23)
- Ben Murdoch-Masila (elbow, round 24-25)
- Jazz Tevaga (shoulder, season)
- Ronald Volkman (shoulder, season)
- Tommy Talau (knee, round 24-25)
- Stefano Utoikamanu (wrist, round 24-25)
- Luke Brooks (calf, round 25)
- Jackson Hastings (ankle, season)
- Alex Twal (concussion, season)
- Shawn Blore (ACL, season)