The State of Origin fate of injured stars Dylan Napa, Michael Morgan, Latrell Mitchell and Reagan Campbell-Gillard was mixed, following an incident-packed Friday night in the NRL.
Maroons prop Napa has suspected syndesmosis, or a high ankle sprain, to his left leg.
He left the ground immediately for scans after a routine run in the first half of a match between the Sydney Roosters and Penrith Panthers.
"We'll have to wait and see how he is tomorrow," Maroons coach Kevin Walters told Fox Sports.
"The next couple of days will be really important given that Origin is only nine days away. I haven't got a lot of time for injuries like this to heal.
"He'll obviously have scans but it doesn't look too good."
Channel Nine commentators predicted a period of between four and six weeks off football for the Brighton Roosters, Aspley Devils and Brisbane Brothers junior.
After the match, Roosters coach Trent Robinson was asked if Napa would be right to face the Blues at ANZ Stadium on June 24.
"Probably not, with the ankle," said Robinson.
"Watching him run out there out on the field there...usually, it'd hold up a little bit better than that if it was a one-weeker.
"He was having trouble running there and that's usually a bit longer I'd say."
Meanwhile, the Origin fate of North Queensland Cowboys fullback Michael Morgan won't be known until he undergoes scans on the biceps injury he suffered in Friday night's loss to the Warriors in Townsville.
Cowboys coach Paul Green said Morgan would have scans over the weekend.
Walters said the injury concern would bring Newcastle fullback Kalyn Ponga into consideration.
"We've got some options and Kalyn Ponga is one guy everyone has been talking about," Walters said.
"He is a similar style of player to Morgo in terms of covering a few positions."
New South Wales centre Mitchell - who was taken from the field on a stretcher with a neck injury in the second half - appears set to take his place in the Blues side next Sunday night.
He posted comments to his fans on social media late on Friday night.
"Hey everyone, just would like to say I'm feeling the love, gratefully nothing is serious,'' he wrote.
''Couple days with a stiff neck but happy that's all it will be!!"
Blues prop Reagan Campbell-Gillard will also await the results of scans after suffering a suspected broken jaw.
Campbell-Gillard collided with Roosters forward Jared Waerea-Hargreaves from a kick restart in the first half and left the field in the 21st minute for a head injury assessment, later confirmed as a jaw injury.
"I've just seen him and he's not in a good way," NSW Blues coach Brad Fittler told Channel Nine.
"He can clench his jaw, which is a good thing, but he's in a bit of pain. He'll have scans tomorrow and we'll have to see how it goes."